8 companies headquartered in Spain are in the RemoteWork directory. None of them has a live role on RemoteWork at the moment, but each company page tells you who to contact and what to say if you reach out anyway.
E-commerce is the most common sector (2). Barcelona is the most common city (1). Most common funding stage: Pre-Seed. Between them they have raised about $1.2B in disclosed funding; the best funded are Glovo ($1.2B).
1 of them hires from Nigeria or elsewhere in Africa. Headquarters is only where the company is registered; most of these hire remotely across time zones, so read each company page for where it actually hires.